Cert Medical Oncology(SA) Paed Practice Questions - CMSA Sub-specialty Certificate In Medical Oncology Cert Medical Oncology(SA) Paed - South Africa Exam

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An 8-year-old boy presents with rapid abdominal distension, ascites, and an ileocecal mass causing intussusception. Biopsy reveals medium-sized lymphoid cells with amphophilic cytoplasm, multiple nucleoli, a high mitotic index (>99% Ki-67 positivity), and interspersed tingible body macrophages ('starry-sky' pattern). What is the characteristic chromosomal translocation?

t(8;14)(q24;q32) translocating MYC to the IGH heavy chain locus t(14;18)(q32;q21) translocating BCL2 to IGH t(11;14)(q13;q32) translocating CCND1 to IGH t(2;5)(p23;q35) translocating NPM1 to ALK

Correct Answer:

t(8;14)(q24;q32) translocating MYC to the IGH heavy chain locus

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