Cert Clin Haematology(SA) Path Practice Questions - CMSA Sub-specialty Certificate In Clinical Haematology (Pathology) Exam

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In a bone marrow aspirate stain evaluated for myelodysplastic neoplasm (MDS), ring sideroblasts are identified using Prussian blue (Perls') reaction. How are ring sideroblasts strictly defined morphologically?

Erythroblasts with coarse basophilic stippling visible on Romanowsky staining Erythroblasts containing > 10 cytoplasmic ferritin aggregates scattered randomly Erythroblasts with any visible perinuclear iron deposit regardless of count Erythroblasts with 5 or more iron granules encircling at least one-third (120 degrees) of the nucleus

Correct Answer:

Erythroblasts with 5 or more iron granules encircling at least one-third (120 degrees) of the nucleus

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