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Question 1
A peripheral blood film from an adult presenting with severe anemia and jaundice demonstrates numerous schistocytes, helmet cells, and polychromasia. What is the minimum percentage of schistocytes required on blood film examination to support a clinical diagnosis of Microangiopathic Hemolytic Anemia (MAHA)?
Correct Answer:
> 1.0%
Question 2
In a bone marrow aspirate stain evaluated for myelodysplastic neoplasm (MDS), ring sideroblasts are identified using Prussian blue (Perls') reaction. How are ring sideroblasts strictly defined morphologically?
Correct Answer:
Erythroblasts with 5 or more iron granules encircling at least one-third (120 degrees) of the nucleus
Question 3
Which cytochemical stain pattern is classic for acute promyelocytic leukemia (APL) with PML-RARA fusion?
Correct Answer:
Strongly, diffusely Myeloperoxidase (MPO) positive and Sudan Black B (SBB) positive
Question 4
On a bone marrow aspirate, giant metamyelocytes, hypersegmented neutrophils, and nuclear-cytoplasmic asynchronous erythroid precursors (Megaloblasts) are observed. Which nutritional deficiency is most strongly associated with these morphological findings?
Correct Answer:
Vitamin B12 (Cobalamin) or Folate deficiency
Question 5
Flow cytometric analysis of a bone marrow aspirate demonstrates an abnormal blast population expressing CD34, HLA-DR, CD117, CD13, and CD33, but negative for CD3, CD19, CD20, and MPO. What lineage assignment is established by CD117 and CD13/CD33 expression?
Correct Answer:
Myeloid lineage
Question 1
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About this Exam

Prepare with the Cert Clin Haematology(SA) Path Practice Questions - CMSA Sub-specialty Certificate in Clinical Haematology (Pathology) Exam practice quiz. This question bank includes 100 questions covering bone, marrow, blood, leukemia, and cells. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Cert Clin Haematology(SA) Path Practice Questions - CMSA Sub-specialty Certificate in Clinical Haematology (Pathology) Exam

This practice set contains 100 questions from the matching question bank and focuses on bone, marrow, blood, leukemia, and cells. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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