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TEP Patologia Practice Questions - TEP - Título De Especialista Em Patologia (Sociedade Brasileira De Patologia AMB) Exam

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A researcher is studying apoptosis pathways in lymphoid cells exposed to DNA-damaging radiation. The signaling cascade involves cellular stress, activation of pro-apoptotic BH3-only proteins (such as BIM, BID, and PUMA), neutralization of anti-apoptotic BCL-2/BCL-XL, permeabilization of the outer mitochondrial membrane via BAX and BAK oligomerization, and cytoplasmic release of cytochrome c. Which initiator caspase is directly activated by the downstream formation of the apoptosome complex (cytochrome c + APAF-1)?
Correct Answer:
Caspase-9

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