Question 1
During a routine microscopic review of a myocardial biopsy from a patient who suffered an acute myocardial infarction 24 hours prior, the pathologist observes preservation of the basic structural outline of necrotic cardiomyocytes with loss of nuclei (karyolysis) and intense cytoplasmic eosinophilia, accompanied by an early neutrophilic infiltrate. What type of necrosis is depicted by these morphological findings?
Correct Answer:
Coagulative necrosis
Question 2
A researcher is studying apoptosis pathways in lymphoid cells exposed to DNA-damaging radiation. The signaling cascade involves cellular stress, activation of pro-apoptotic BH3-only proteins (such as BIM, BID, and PUMA), neutralization of anti-apoptotic BCL-2/BCL-XL, permeabilization of the outer mitochondrial membrane via BAX and BAK oligomerization, and cytoplasmic release of cytochrome c. Which initiator caspase is directly activated by the downstream formation of the apoptosome complex (cytochrome c + APAF-1)?
Correct Answer:
Caspase-9
Question 3
An endoscopic biopsy of the distal esophagus in a 55-year-old patient with long-standing gastroesophageal reflux disease reveals replacement of the normal non-keratinized stratified squamous epithelium by simple columnar epithelium containing distinct goblet cells (intestinal metaplasia). How is this adaptive cellular process best classified?
Correct Answer:
Metaplasia
Question 4
During the vascular and cellular response of acute inflammation, circulating leukocytes exit the microvasculature to reach the site of injury. Which family of endothelial adhesion molecules is primarily responsible for the initial loose attachment and rolling of neutrophils along the activated endothelium?
Correct Answer:
Selectins (E-selectin and P-selectin)
Question 5
Histopathological examination of a lung nodule resected from a 42-year-old patient reveals well-formed granulomas composed of aggregated epithelioid histiocytes, Langhans multinucleated giant cells with horseshoe-arranged peripheral nuclei, and central acellular granular caseous necrosis. Which cytokine produced by CD4+ T-helper 1 (Th1) cells is the principal mediator driving the transformation of recruited macrophages into epithelioid cells and giant cells in this setting?
Correct Answer:
Interferon-gamma (IFN-γ)
Question 1
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Prepare with the TEP Patologia Practice Questions - TEP - Título de Especialista em Patologia (Sociedade Brasileira de Patologia AMB) Exam practice quiz. This question bank includes 100 questions covering cells, year-old, reveals, tumor, and nuclear. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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TEP Patologia Practice Questions - TEP - Título de Especialista em Patologia (Sociedade Brasileira de Patologia AMB) Exam

This practice set contains 100 questions from the matching question bank and focuses on cells, year-old, reveals, tumor, and nuclear. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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