USMLE Step 3 Practice Questions - United States Medical Licensing Examination Step 3 Exam

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A randomized controlled trial of a new anticoagulant for stroke prevention in atrial fibrillation reports the following results: 2.5% annual stroke rate in the treatment group vs. 4.0% in the warfarin control group (p=0.02). The 95% confidence interval for the relative risk reduction is 15% to 55%. Which conclusion is most appropriate?

The new drug is superior to warfarin The new drug is equivalent to warfarin The new drug is non-inferior to warfarin No conclusion can be drawn due to wide confidence intervals

Correct Answer:

The new drug is superior to warfarin

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