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Question 1
A new screening test for colorectal cancer is being evaluated. In a study of 10,000 patients, the test results were compared to colonoscopy (gold standard). The screening test was positive in 180 patients, of whom 90 had cancer on colonoscopy. The test was negative in 9,820 patients, of whom 40 had cancer on colonoscopy. What is the negative predictive value of this screening test?
Correct Answer:
99.6%
Question 2
A pharmaceutical company is testing a new drug for migraine prevention. The primary outcome is reduction in migraine frequency. The study enrolls 400 patients: 200 receive the new drug and 200 receive placebo. After 6 months, 120 patients in the treatment group and 80 in the placebo group show ≥50% reduction in migraine frequency. What is the number needed to treat (NNT)?
Correct Answer:
5
Question 3
A case-control study examines the association between NSAID use and peptic ulcer disease. Cases (n=200) are patients with confirmed peptic ulcers; controls (n=400) are age-matched patients without ulcers. The study finds that 120 cases and 80 controls reported regular NSAID use. What measure of association can be calculated from this study design?
Correct Answer:
Odds ratio
Question 4
A randomized controlled trial of a new anticoagulant for stroke prevention in atrial fibrillation reports the following results: 2.5% annual stroke rate in the treatment group vs. 4.0% in the warfarin control group (p=0.02). The 95% confidence interval for the relative risk reduction is 15% to 55%. Which conclusion is most appropriate?
Correct Answer:
The new drug is superior to warfarin
Question 5
A screening program for breast cancer using mammography is implemented in a community. The test has 85% sensitivity and 90% specificity. If the prevalence of breast cancer in this population is 1%, what is the probability that a woman with a positive screening test actually has breast cancer?
Correct Answer:
8%
Question 1
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Prepare with the USMLE Step 3 Practice Questions - United States Medical Licensing Examination Step 3 Exam practice quiz. This question bank includes 100 questions covering year-old, shows, presents, woman, and studies. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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USMLE Step 3 Practice Questions - United States Medical Licensing Examination Step 3 Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, shows, presents, woman, and studies. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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