ABP Pediatric Endocrinology Practice Questions - ABP Pediatric Endocrinology Subspecialty Certification Examination Exam

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A 9-year-old presents with polyuria, polydipsia, and 5 kg weight loss over 3 weeks. Glucose is 412 mg/dL, pH 7.18, HCO3 10, ketones large, and islet autoantibodies are positive for GAD65, IA2, and ZnT8. Which statement best characterizes the immunologic basis of this disease?

Amyloid deposition within islets impairing insulin secretion Autoantibody-mediated complement lysis of beta cells T-cell mediated autoimmune destruction of pancreatic beta cells, with autoantibodies serving as disease markers rather than the primary effectors Congenital agenesis of the dorsal pancreatic anlage

Correct Answer:

T-cell mediated autoimmune destruction of pancreatic beta cells, with autoantibodies serving as disease markers rather than the primary effectors

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