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ABPath Neuropathology Practice Questions - ABPath Neuropathology Subspecialty Certification Examination Exam

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A 9-year-old child has a midline pontine infiltrative tumor. Biopsy shows a high-grade diffuse astrocytic neoplasm. IHC shows loss of H3 K27me3 and positivity for H3 K27M. This defines which WHO CNS 2021 entity?
Correct Answer:
Diffuse midline glioma, H3 K27-altered, CNS WHO grade 4

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