Question 1
A 42-year-old woman presents with a new-onset seizure. MRI shows a non-enhancing, T2-hyperintense, infiltrative mass in the right frontal lobe. Biopsy shows a moderately cellular astrocytic neoplasm with atypia but no microvascular proliferation or necrosis. IHC shows IDH1 R132H positive and ATRX loss. 1p/19q is retained. Which diagnosis per WHO CNS 2021 is most appropriate?
Correct Answer:
Astrocytoma, IDH-mutant, CNS WHO grade 2
Question 2
A 55-year-old man has a left frontal cortical tumor with calcifications on CT. Histology shows monotonous round cells with perinuclear halos ('fried egg'), chicken-wire capillaries, and microcalcifications. Molecular testing shows IDH1 mutation and 1p/19q codeletion. Which diagnosis is correct?
Correct Answer:
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted
Question 3
A 65-year-old man has a rapidly growing, ring-enhancing right temporal mass. Biopsy shows a highly cellular astrocytic tumor with microvascular proliferation, pseudopalisading necrosis, and brisk mitoses. IDH1/2 are wild-type. Which molecular finding is sufficient by WHO CNS 2021 criteria to classify this as glioblastoma, IDH-wildtype grade 4, even without necrosis or microvascular proliferation?
Correct Answer:
TERT promoter mutation, EGFR amplification, or +7/-10 chromosome signature
Question 4
A 9-year-old child has a midline pontine infiltrative tumor. Biopsy shows a high-grade diffuse astrocytic neoplasm. IHC shows loss of H3 K27me3 and positivity for H3 K27M. This defines which WHO CNS 2021 entity?
Correct Answer:
Diffuse midline glioma, H3 K27-altered, CNS WHO grade 4
Question 5
A 22-year-old presents with a hemispheric high-grade glioma. Sequencing shows H3.3 G34R mutation with ATRX loss and TP53 mutation. Which WHO CNS 2021 tumor is this?
Correct Answer:
Diffuse hemispheric glioma, H3 G34-mutant, CNS WHO grade 4
Question 1
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Prepare with the ABPath Neuropathology Practice Questions - ABPath Neuropathology Subspecialty Certification Examination Exam practice quiz. This question bank includes 100 questions covering shows, year-old, diagnosis, tumor, and biopsy. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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ABPath Neuropathology Practice Questions - ABPath Neuropathology Subspecialty Certification Examination Exam

This practice set contains 100 questions from the matching question bank and focuses on shows, year-old, diagnosis, tumor, and biopsy. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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