Cert Medical Oncology(SA) Paed Practice Questions - CMSA Sub-specialty Certificate In Medical Oncology Cert Medical Oncology(SA) Paed - South Africa Exam

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A 6-month-old infant is diagnosed with acute lymphoblastic leukaemia. Immunophenotyping shows CD19+, CD22+, HLA-DR+, but CD10 (CALLA) negative blasts. Which molecular genetic alteration is found in over 70-80% of infant ALL cases and accounts for its dismal prognosis?

High hyperdiploidy (>50 chromosomes) NUP98-NSD1 gene fusion ETV6-RUNX1 translocation t(12;21) KMT2A (MLL) gene rearrangement on chromosome 11q23

Correct Answer:

KMT2A (MLL) gene rearrangement on chromosome 11q23

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