ABPath Neuropathology Practice Questions - ABPath Neuropathology Subspecialty Certification Examination Exam

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A 65-year-old man has a rapidly growing, ring-enhancing right temporal mass. Biopsy shows a highly cellular astrocytic tumor with microvascular proliferation, pseudopalisading necrosis, and brisk mitoses. IDH1/2 are wild-type. Which molecular finding is sufficient by WHO CNS 2021 criteria to classify this as glioblastoma, IDH-wildtype grade 4, even without necrosis or microvascular proliferation?

ATRX loss TERT promoter mutation, EGFR amplification, or +7/-10 chromosome signature MGMT promoter methylation BRAF V600E mutation

Correct Answer:

TERT promoter mutation, EGFR amplification, or +7/-10 chromosome signature

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