FRCS Neurosurgery Practice Questions - Intercollegiate Specialty Fellowship Examination In Neurosurgery (FRCS SN) Exam

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A 58-year-old presents with a 6-week history of progressive headache and dysphasia. MRI shows a peripherally enhancing left temporal mass with central necrosis and surrounding T2/FLAIR signal. Histology confirms a WHO grade 4 IDH-wildtype astrocytic tumour. Which molecular marker most strongly predicts benefit from temozolomide and a better prognosis?

MGMT promoter methylation EGFR amplification TERT promoter mutation Chromosome 10 loss

Correct Answer:

MGMT promoter methylation

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