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Question 1
A 58-year-old presents with a 6-week history of progressive headache and dysphasia. MRI shows a peripherally enhancing left temporal mass with central necrosis and surrounding T2/FLAIR signal. Histology confirms a WHO grade 4 IDH-wildtype astrocytic tumour. Which molecular marker most strongly predicts benefit from temozolomide and a better prognosis?
Correct Answer:
MGMT promoter methylation
Question 2
According to the WHO 2021 classification of CNS tumours, which combination of molecular features defines a 1p/19q-codeleted oligodendroglioma?
Correct Answer:
IDH-mutant with whole-arm codeletion of 1p and 19q
Question 3
A 45-year-old has a well-circumscribed, dural-based, homogeneously enhancing extra-axial mass with a dural tail on MRI. At operation the lesion is firm and attached to the dura. Which is the single most appropriate grading system to apply to the resection achieved?
Correct Answer:
Simpson grading
Question 4
A 35-year-old presents with progressive hearing loss, tinnitus and unsteadiness. MRI shows an enhancing mass in the left cerebellopontine angle extending into the internal auditory meatus, with an 'ice-cream cone' appearance. Which cranial nerve does this tumour most commonly arise from?
Correct Answer:
Superior vestibular division of cranial nerve VIII
Question 5
A 30-year-old woman has secondary amenorrhoea and galactorrhoea. Serum prolactin is markedly elevated at 8,000 mU/L and MRI shows a 1.5 cm pituitary macroadenoma. There is no visual field defect. What is the most appropriate first-line management?
Correct Answer:
Dopamine agonist (cabergoline)
Question 1
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About this Exam

Prepare with the FRCS Neurosurgery Practice Questions - Intercollegiate Specialty Fellowship Examination in Neurosurgery (FRCS SN) Exam practice quiz. This question bank includes 100 questions covering year-old, shows, presents, patient, and pain. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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FRCS Neurosurgery Practice Questions - Intercollegiate Specialty Fellowship Examination in Neurosurgery (FRCS SN) Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, shows, presents, patient, and pain. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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