TEOC Oncologia Clínica Practice Questions - TEOC - Título De Especialista Em Oncologia Clínica (Sociedade Brasileira De Oncologia Clínica AMB) Exam

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A 34-year-old premenopausal woman with high-risk luminal B breast cancer (ER 90%, PR 10%, HER2 0, grade 3, pT2 pN1a with 3 positive lymph nodes) completes adjuvant chemotherapy and radiotherapy. Her menstrual cycles resume 3 months later. Based on the joint analysis of the SOFT and TEXT trials, which endocrine therapy strategy provides the greatest reduction in breast cancer recurrence?

Tamoxifen 20 mg daily alone for 5 years Ovarian function suppression (GnRH agonist) plus an aromatase inhibitor (exemestane) for 5 years Ovarian function suppression (GnRH agonist) plus tamoxifen for 2 years followed by tamoxifen alone Anastrozole 1 mg daily alone without ovarian suppression

Correct Answer:

Ovarian function suppression (GnRH agonist) plus an aromatase inhibitor (exemestane) for 5 years

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