Arab Board Oncology Clinical Practice Questions - Arab Board Medical Oncology Final Practical Clinical Examination - الامتحان النهائي العملي لاختصاص طب الأورام (ABHS) Exam

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A 52-year-old postmenopausal woman undergoes lumpectomy and sentinel lymph node biopsy for a 2.1 cm invasive ductal carcinoma. Pathology reveals grade 2 carcinoma, ER 95%, PR 80%, HER2-negative (IHC 0), and 1 sentinel lymph node containing a 1.2 mm micrometastasis (pN1mi). Genomic profiling reveals a 21-gene Recurrence Score (RS) of 14. What is the most appropriate adjuvant systemic therapy?

Adjuvant endocrine therapy alone with an aromatase inhibitor Adjuvant dose-dense AC followed by paclitaxel plus endocrine therapy Adjuvant TC (docetaxel and cyclophosphamide) plus endocrine therapy Adjuvant ovarian function suppression plus tamoxifen

Correct Answer:

Adjuvant endocrine therapy alone with an aromatase inhibitor

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