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TEP Patologia Practice Questions - TEP - Título De Especialista Em Patologia (Sociedade Brasileira De Patologia AMB) Exam

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Histopathological examination of a lung nodule resected from a 42-year-old patient reveals well-formed granulomas composed of aggregated epithelioid histiocytes, Langhans multinucleated giant cells with horseshoe-arranged peripheral nuclei, and central acellular granular caseous necrosis. Which cytokine produced by CD4+ T-helper 1 (Th1) cells is the principal mediator driving the transformation of recruited macrophages into epithelioid cells and giant cells in this setting?
Correct Answer:
Interferon-gamma (IFN-γ)

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