Cert Medical Oncology(SA) Paed Practice Questions - CMSA Sub-specialty Certificate In Medical Oncology Cert Medical Oncology(SA) Paed - South Africa Exam

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A 4-year-old boy presents with pallor, lethargy, fever, and diffuse petechiae. Bone marrow aspirate confirms precursor B-cell acute lymphoblastic leukaemia (B-ALL). Cytogenetic analysis reveals a t(12;21)(p13;q22) translocation. Which gene fusion is formed by this translocation, and what is its prognostic significance?

ETV6-RUNX1 (TEL-AML1); favorable prognosis TCF3-PBX1 (E2A-PBX1); unfavorable prognosis KMT2A-AFF1 (MLL-AF4); favorable prognosis BCR-ABL1; unfavorable prognosis

Correct Answer:

ETV6-RUNX1 (TEL-AML1); favorable prognosis

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