Título De Especialista Em Infectologia SBI Practice Questions - Título De Especialista Em Infectologia (SBI AMB) Exam

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A 44-year-old man living with HIV on TDF + 3TC + DTG for 3 years experiences confirmed virologic failure with an HIV RNA viral load of 42,000 copies/mL. Genotypic resistance testing reveals the reverse transcriptase mutation M184V and the integrase strand transfer inhibitor mutations G118R and R263K. According to national Brazilian salvage guidelines, which of the following represents the most appropriate salvage ART regimen?

Boosted Darunavir (DRV/r 600/100 mg twice daily) + Dolutegravir (DTG 50 mg twice daily) + Tenofovir (TDF) + Lamivudine (3TC) Switch back to Efavirenz (600 mg once daily) + Zidovudine (300 mg twice daily) + Lamivudine (150 mg twice daily) Continue Dolutegravir (50 mg once daily) and add Raltegravir (400 mg twice daily) plus Maraviroc Switch to Abacavir (ABC) + Lamivudine (3TC) + Nevirapine (NVP) monotherapy

Correct Answer:

Boosted Darunavir (DRV/r 600/100 mg twice daily) + Dolutegravir (DTG 50 mg twice daily) + Tenofovir (TDF) + Lamivudine (3TC)

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