Título de Especialista em Infectologia SBI Practice Questions - Título de Especialista em Infectologia (SBI AMB) Exam - Título de Especialista em Infectologia SBI Practice Questions - Título de Especialista em Infectologia (SBI AMB) Exam

Question 1

According to the Brazilian Ministry of Health Clinical Protocol and Therapeutic Guidelines (PCDT) for HIV/AIDS in adults, which of the following is the standard first-line antiretroviral therapy (ART) regimen for a treatment-naïve adult living with HIV with no active opportunistic infections and normal renal function?

Dolutegravir (DTG 50 mg) + Lamivudine (3TC 300 mg) + Tenofovir disoproxil fumarate (TDF 300 mg) once daily Efavirenz (EFV 600 mg) + Lamivudine (3TC 300 mg) + Tenofovir disoproxil fumarate (TDF 300 mg) once daily Darunavir boosted with ritonavir (DRV/r 800/100 mg) + Zidovudine (AZT 300 mg) + Lamivudine (3TC 150 mg) twice daily Bictegravir (BIC 50 mg) + Emtricitabine (FTC 200 mg) + Tenofovir alafenamide (TAF 25 mg) once daily

Correct Answer:

Dolutegravir (DTG 50 mg) + Lamivudine (3TC 300 mg) + Tenofovir disoproxil fumarate (TDF 300 mg) once daily

Question 2

A 26-year-old cisgender man who has sex with men presents to an infectious diseases clinic in São Paulo requesting HIV Pre-Exposure Prophylaxis (PrEP). He is asymptomatic, his rapid HIV test is negative, serum creatinine is 0.9 mg/dL, and HBsAg is negative. According to the Brazilian PCDT guidelines, what is the recommended continuous oral PrEP regimen and baseline clinical requirement?

Tenofovir disoproxil fumarate 300 mg / Emtricitabine 200 mg (TDF/FTC) fixed-dose combination, one tablet orally once daily, requiring confirmed HIV-negative status and normal renal function Dolutegravir 50 mg + Lamivudine 300 mg once daily, requiring baseline viral load testing Zidovudine 300 mg / Lamivudine 150 mg twice daily, requiring complete blood count monitoring for myelosuppression Tenofovir disoproxil fumarate 300 mg monotherapy once daily, without need for baseline creatinine evaluation

Correct Answer:

Tenofovir disoproxil fumarate 300 mg / Emtricitabine 200 mg (TDF/FTC) fixed-dose combination, one tablet orally once daily, requiring confirmed HIV-negative status and normal renal function

Question 3

A 31-year-old female nurse sustains a deep percutaneous needle stick injury with a hollow-bore needle visibly contaminated with blood from an HIV-positive patient whose viral load is 85,000 copies/mL. The injury occurred 4 hours ago. According to Brazilian PCDT protocols for Post-Exposure Prophylaxis (PEP), what is the most appropriate management?

Initiate Tenofovir disoproxil fumarate (300 mg) + Lamivudine (300 mg) + Dolutegravir (50 mg) once daily for exactly 28 days, initiated within 72 hours of exposure Initiate Zidovudine + Lamivudine + Efavirenz for 14 days, provided the source patient's CD4 count is < 200 cells/mm³ Perform immediate baseline HIV PCR and delay antiretroviral prophylaxis until test results confirm transmission Administer a single loading dose of intramuscular Cabotegravir and prescribe oral Raltegravir for 7 days

Correct Answer:

Initiate Tenofovir disoproxil fumarate (300 mg) + Lamivudine (300 mg) + Dolutegravir (50 mg) once daily for exactly 28 days, initiated within 72 hours of exposure

Question 4

A 44-year-old man living with HIV on TDF + 3TC + DTG for 3 years experiences confirmed virologic failure with an HIV RNA viral load of 42,000 copies/mL. Genotypic resistance testing reveals the reverse transcriptase mutation M184V and the integrase strand transfer inhibitor mutations G118R and R263K. According to national Brazilian salvage guidelines, which of the following represents the most appropriate salvage ART regimen?

Boosted Darunavir (DRV/r 600/100 mg twice daily) + Dolutegravir (DTG 50 mg twice daily) + Tenofovir (TDF) + Lamivudine (3TC) Switch back to Efavirenz (600 mg once daily) + Zidovudine (300 mg twice daily) + Lamivudine (150 mg twice daily) Continue Dolutegravir (50 mg once daily) and add Raltegravir (400 mg twice daily) plus Maraviroc Switch to Abacavir (ABC) + Lamivudine (3TC) + Nevirapine (NVP) monotherapy

Correct Answer:

Boosted Darunavir (DRV/r 600/100 mg twice daily) + Dolutegravir (DTG 50 mg twice daily) + Tenofovir (TDF) + Lamivudine (3TC)

Question 5

A 38-year-old woman is newly diagnosed with HIV infection during an outpatient workup. Her laboratory panel demonstrates a CD4+ T-cell count of 110 cells/mm³ and an HIV viral load of 320,000 copies/mL. She is currently asymptomatic without cough, fever, or dyspnea. According to PCDT guidelines, which antimicrobial is the first-line primary prophylaxis against Pneumocystis jirovecii pneumonia (PCP)?

Trimethoprim-sulfamethoxazole (SMX-TMP 800/160 mg), 1 tablet orally once daily Aerosolized Pentamidine 300 mg once monthly via nebulizer Dapsone 100 mg orally once weekly Atovaquone 750 mg orally twice daily

Correct Answer:

Trimethoprim-sulfamethoxazole (SMX-TMP 800/160 mg), 1 tablet orally once daily

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Prepare with the Título de Especialista em Infectologia SBI Practice Questions - Título de Especialista em Infectologia (SBI AMB) Exam practice quiz. This question bank includes 100 questions covering year-old, brazilian, therapy, health, and clinical. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Título de Especialista em Infectologia SBI Practice Questions - Título de Especialista em Infectologia (SBI AMB) Exam

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Título de Especialista em Infectologia SBI Practice Questions - Título de Especialista em Infectologia (SBI AMB) Exam

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