Cert ID(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Infectious Diseases Cert ID(SA) Phys - South Africa Exam

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A 42-year-old HIV-infected man with CD4 count 18 cells/µL is admitted with severe cryptococcal meningitis confirmed on India ink and CSF CrAg. CSF opening pressure is 32 cm H2O. What is the preferred induction antifungal regimen according to current Southern African HIV Clinicians Society guidelines?

Amphotericin B deoxycholate 1 mg/kg/day IV plus Fluconazole 800 mg/day for 4 weeks Fluconazole 1200 mg daily monotherapy for 14 days Voriconazole 400 mg IV twice daily for 7 days followed by oral Itraconazole Single high-dose Liposomal Amphotericin B (10 mg/kg) on day 1 PLUS Flucytosine 100 mg/kg/day and Fluconazole 1200 mg/kg/day for 14 days (AMBITION-cm trial regimen)

Correct Answer:

Single high-dose Liposomal Amphotericin B (10 mg/kg) on day 1 PLUS Flucytosine 100 mg/kg/day and Fluconazole 1200 mg/kg/day for 14 days (AMBITION-cm trial regimen)

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