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Question 1
A 34-year-old HIV-positive man (CD4 count 45 cells/µL, ART-naïve) presents with a 3-week history of productive cough, fever, and night sweats. Sputum Xpert MTB/RIF Ultra detects Mycobacterium tuberculosis complex with 'Rifampicin resistance DETECTED'. Second-line line probe assay (LPA) reveals fluoroquinolone susceptibility and no resistance to amikacin. Which of the following is the most appropriate initial treatment regimen for this patient according to updated South African national drug-resistant TB guidelines?
Correct Answer:
Bedaquiline, Pretomanid, Linezolid, and Moxifloxacin (BPaLM) for 6 months
Question 2
A 29-year-old woman with newly diagnosed HIV infection presents for ART initiation. She is completely asymptomatic. Her CD4 count returns at 38 cells/µL. Serum Cryptococcal Antigen (CrAg) screening is positive. She has no headache, fever, neck stiffness, or altered mental status. What is the most appropriate next step in management?
Correct Answer:
Perform a diagnostic lumbar puncture to measure opening pressure and rule out subclinical cryptococcal meningitis
Question 3
A 42-year-old HIV-infected man with CD4 count 18 cells/µL is admitted with severe cryptococcal meningitis confirmed on India ink and CSF CrAg. CSF opening pressure is 32 cm H2O. What is the preferred induction antifungal regimen according to current Southern African HIV Clinicians Society guidelines?
Correct Answer:
Single high-dose Liposomal Amphotericin B (10 mg/kg) on day 1 PLUS Flucytosine 100 mg/kg/day and Fluconazole 1200 mg/kg/day for 14 days (AMBITION-cm trial regimen)
Question 4
A 38-year-old man with advanced HIV infection (CD4 count 12 cells/µL) is treated for confirmed Cryptococcal Meningitis. Induction therapy is successfully completed, CSF opening pressure has normalized, and he is clinically well on Fluconazole consolidation therapy. When should antiretroviral therapy (ART) be initiated in this patient?
Correct Answer:
4 to 6 weeks after the initiation of antifungal induction therapy
Question 5
A 50-year-old woman with pre-XDR pulmonary tuberculosis (rifampicin-resistant and moxifloxacin-resistant) is started on an individualized treatment regimen containing Linezolid 600 mg daily, Bedaquiline, Pretomanid, Clofazimine, and Terizidone. Four weeks into therapy, she develops progressive numbness, tingling, and burning pain in both feet, along with routine laboratory monitoring showing hemoglobin drop from 11.5 g/dL to 8.1 g/dL. Which drug is responsible for these adverse effects, and what is the optimal management?
Correct Answer:
Linezolid; reduce dose to 300 mg daily (or temporary hold if severe) and administer Pyridoxine (Vitamin B6)
Question 1
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Prepare with the Cert ID(SA) Phys Practice Questions - CMSA Sub-specialty Certificate in Infectious Diseases Cert ID(SA) Phys - South Africa Exam practice quiz. This question bank includes 100 questions covering year-old, presents, cells, patient, and count. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Cert ID(SA) Phys Practice Questions - CMSA Sub-specialty Certificate in Infectious Diseases Cert ID(SA) Phys - South Africa Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, presents, cells, patient, and count. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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