ABP Pediatric Hematology-Oncology Practice Questions - ABP Pediatric Hematology-Oncology Subspecialty Certification Examination Exam

A 3-month-old infant presents with hyperleukocytosis and B-ALL with KMT2A (MLL) rearrangement. Which statement is TRUE?

Infant KMT2A-rearranged ALL has a poor prognosis and is treated on infant-specific protocols It has an excellent prognosis similar to ETV6-RUNX1 It is a T-cell disease It responds best to single-agent methotrexate

Correct Answer:

Infant KMT2A-rearranged ALL has a poor prognosis and is treated on infant-specific protocols

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