Question 1
A 5-year-old with B-cell precursor ALL has blasts showing t(12;21)(p13;q22) ETV6-RUNX1 fusion. Which prognostic category does this cytogenetic finding indicate?
Correct Answer:
Favorable prognosis
Question 2
A 4-year-old with newly diagnosed B-ALL has blasts positive for BCR-ABL1 (Philadelphia chromosome, t(9;22)). What targeted agent should be added to chemotherapy?
Correct Answer:
Dasatinib (tyrosine kinase inhibitor)
Question 3
A 3-month-old infant presents with hyperleukocytosis and B-ALL with KMT2A (MLL) rearrangement. Which statement is TRUE?
Correct Answer:
Infant KMT2A-rearranged ALL has a poor prognosis and is treated on infant-specific protocols
Question 4
At end-of-induction for pediatric B-ALL, flow cytometric MRD shows 0.05% residual blasts. What does this finding indicate?
Correct Answer:
Poor prognosis and need for treatment intensification
Question 5
Tisagenlecleucel is approved for pediatric relapsed/refractory B-ALL. What is its mechanism?
Correct Answer:
Autologous T cells engineered to express a CD19-directed chimeric antigen receptor
Question 1
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About this Exam

Prepare with the ABP Pediatric Hematology-Oncology Practice Questions - ABP Pediatric Hematology-Oncology Subspecialty Certification Examination Exam practice quiz. This question bank includes 100 questions covering year-old, shows, tumor, presents, and pediatric. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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ABP Pediatric Hematology-Oncology Practice Questions - ABP Pediatric Hematology-Oncology Subspecialty Certification Examination Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, shows, tumor, presents, and pediatric. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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