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TEOC Oncologia Clínica Practice Questions - TEOC - Título De Especialista Em Oncologia Clínica (Sociedade Brasileira De Oncologia Clínica AMB) Exam

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A 38-year-old woman with a documented germline BRCA1 pathogenic mutation is diagnosed with triple-negative invasive breast cancer. She completes neoadjuvant dose-dense AC followed by carboplatin/paclitaxel and undergoes mastectomy with sentinel node biopsy. Surgical pathology reveals a 1.2 cm residual invasive carcinoma in the breast and 1 micrometastatic lymph node (non-pCR, residual cancer burden class II). According to the OlympiA trial, which adjuvant targeted therapy provides a proven overall survival benefit?
Correct Answer:
Olaparib 300 mg twice daily orally for 1 year

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