Cert ID(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Infectious Diseases Cert ID(SA) Phys - South Africa Exam

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A 34-year-old HIV-positive man (CD4 count 45 cells/µL, ART-naïve) presents with a 3-week history of productive cough, fever, and night sweats. Sputum Xpert MTB/RIF Ultra detects Mycobacterium tuberculosis complex with 'Rifampicin resistance DETECTED'. Second-line line probe assay (LPA) reveals fluoroquinolone susceptibility and no resistance to amikacin. Which of the following is the most appropriate initial treatment regimen for this patient according to updated South African national drug-resistant TB guidelines?

Standard 9-month injectable-containing regimen (Amikacin, Moxifloxacin, Ethionamide, Terizidone) Bedaquiline, Pretomanid, Linezolid, and Moxifloxacin (BPaLM) for 6 months Longer individualised regimen of 18-24 months containing Bedaquiline, Levofloxacin, Linezolid, Clofazimine, and Cycloserine Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol at double doses

Correct Answer:

Bedaquiline, Pretomanid, Linezolid, and Moxifloxacin (BPaLM) for 6 months

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