Cert Gastroenterology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Gastroenterology Cert Gastroenterology(SA) Phys - South Africa Exam

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A 29-year-old female with steroid-refractory acute severe ulcerative colitis on Day 3 of high-dose IV hydrocortisone is evaluated for medical rescue therapy. Stool PCR for Clostridioides difficile and rectal biopsies for CMV IHC are negative. Which statement correctly describes the comparative efficacy of intravenous Infliximab versus intravenous Ciclosporin in this setting?

Infliximab and Ciclosporin show equivalent short-term and long-term colectomy-free survival rates Ciclosporin is significantly superior to Infliximab in reducing 90-day colectomy rates Infliximab is significantly superior to Ciclosporin in achieving clinical remission at 7 days Sequential therapy with Infliximab immediately following failed Ciclosporin is standard safe practice

Correct Answer:

Infliximab and Ciclosporin show equivalent short-term and long-term colectomy-free survival rates

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