ACCS Respiratory Practice Exam

Which class of medication is considered first-line therapy for gastroesophageal reflux disease (GERD)?

Antacids H2 receptor antagonists Proton pump inhibitors Prokinetic agents

Correct Answer:

Proton pump inhibitors

Explanation:

Proton pump inhibitors are the go-to initial therapy because they provide strong, sustained suppression of gastric acid by blocking the final step of acid production in the stomach. This level of acid control leads to higher rates of symptom relief and healing of esophageal irritation, which is why they are preferred as first-line treatment for GERD. Antacids offer quick, short-lived relief but don’t promote healing. H2 receptor antagonists reduce acid but are less potent and can lose effectiveness over time. Prokinetic agents can help with motility and some symptoms, but they don’t match the efficacy and tolerability of PPIs for most GERD patients, making them a less favored first option.

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