ABIM Med Oncology Practice Questions - ABIM Medical Oncology Subspecialty Certification Exam

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A 38-year-old premenopausal woman with a 3.5 cm, grade 3, ER 90%, PR 70%, HER2 0, node-positive (2/4) invasive lobular carcinoma completes AC-T chemotherapy. Based on SOFT/TEXT trials, what adjuvant endocrine therapy is most appropriate for this high-risk premenopausal patient?

Tamoxifen 20 mg daily for 5 years Tamoxifen 20 mg daily for 10 years without ovarian suppression Aromatase inhibitor (exemestane) plus ovarian function suppression (GnRH agonist) for 5 years Aromatase inhibitor alone without ovarian suppression

Correct Answer:

Aromatase inhibitor (exemestane) plus ovarian function suppression (GnRH agonist) for 5 years

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