Question 1
A 54-year-old postmenopausal woman has a 2.2 cm, grade 2, ER 95%, PR 80%, HER2 0 by IHC, Ki-67 15% invasive ductal carcinoma with 1 of 3 sentinel nodes positive. Oncotype DX recurrence score is 18. In addition to breast-conserving therapy with whole-breast radiation, which adjuvant systemic therapy is most appropriate?
Correct Answer:
Aromatase inhibitor (letrozole or anastrozole) for at least 5 years
Question 2
A 38-year-old premenopausal woman with a 3.5 cm, grade 3, ER 90%, PR 70%, HER2 0, node-positive (2/4) invasive lobular carcinoma completes AC-T chemotherapy. Based on SOFT/TEXT trials, what adjuvant endocrine therapy is most appropriate for this high-risk premenopausal patient?
Correct Answer:
Aromatase inhibitor (exemestane) plus ovarian function suppression (GnRH agonist) for 5 years
Question 3
A 48-year-old woman with clinical stage II, ER 2%, PR 0%, HER2 0 (triple-negative) breast cancer is planned for neoadjuvant therapy. Based on KEYNOTE-522, which regimen is preferred?
Correct Answer:
Carboplatin + paclitaxel followed by AC plus pembrolizumab, then adjuvant pembrolizumab
Question 4
A 62-year-old woman received neoadjuvant TCHP for clinical T2N1 HER2-positive breast cancer. Surgical pathology shows residual invasive disease in the breast (ypT1cN1). Which adjuvant therapy is most appropriate based on KATHERINE?
Correct Answer:
Trastuzumab emtansine (T-DM1) for 14 cycles
Question 5
A 58-year-old woman with HR+/HER2-low (IHC 1+) metastatic breast cancer has progressed after two prior lines of chemotherapy in the metastatic setting. Which therapy demonstrated OS benefit in DESTINY-Breast04?
Correct Answer:
Trastuzumab deruxtecan (T-DXd)
Question 1
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Prepare with the ABIM Med Oncology Practice Questions - ABIM Medical Oncology Subspecialty Certification Exam practice quiz. This question bank includes 100 questions covering year-old, therapy, metastatic, cancer, and preferred. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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ABIM Med Oncology Practice Questions - ABIM Medical Oncology Subspecialty Certification Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, therapy, metastatic, cancer, and preferred. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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