MRCPCH TAS Practice Questions - MRCPCH Theory And Science (TAS) Exam

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A neonate with a patent ductus arteriosus is treated with intravenous ibuprofen to promote ductal closure. Which pharmacological action explains why this drug closes the duct?

Activation of guanylate cyclase increasing cyclic GMP Stimulation of prostaglandin E2 receptors in ductal smooth muscle Blockade of beta-adrenergic receptors in the ductal wall Inhibition of cyclo-oxygenase, reducing prostaglandin E2 synthesis

Correct Answer:

Inhibition of cyclo-oxygenase, reducing prostaglandin E2 synthesis

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