Question 1
A neonate with a patent ductus arteriosus is treated with intravenous ibuprofen to promote ductal closure. Which pharmacological action explains why this drug closes the duct?
Correct Answer:
Inhibition of cyclo-oxygenase, reducing prostaglandin E2 synthesis
Question 2
Neonates handle many drugs differently from adults. Compared with adults, which pharmacokinetic feature is characteristic of the term neonate?
Correct Answer:
Increased total body water as a proportion of body weight
Question 3
A child is started on phenytoin for seizures. Plotting serum concentration against dose shows that small dose increases cause disproportionately large rises in plasma level. What does this pattern indicate?
Correct Answer:
Zero-order (saturable) elimination kinetics
Question 4
Salbutamol is given to a child with acute asthma. Through which receptor and second messenger does it relieve bronchospasm?
Correct Answer:
Beta-2 adrenoceptor activation increasing intracellular cyclic AMP
Question 5
A 6-year-old develops an acute dystonic reaction (oculogyric crisis and torticollis) shortly after receiving metoclopramide for vomiting. Which drug is the most appropriate immediate treatment?
Correct Answer:
Intravenous procyclidine (an anticholinergic)
Question 1
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Prepare with the MRCPCH TAS Practice Questions - MRCPCH Theory and Science (TAS) Exam practice quiz. This question bank includes 100 questions covering child, neonate, explains, drug, and develops. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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MRCPCH TAS Practice Questions - MRCPCH Theory and Science (TAS) Exam

This practice set contains 100 questions from the matching question bank and focuses on child, neonate, explains, drug, and develops. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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