Medical Oncology SCE Practice Questions - Specialty Certificate Examination In Medical Oncology Exam

Why can BRCA1 or BRCA2 loss make a tumour sensitive to PARP inhibition?

Homologous recombination repair is impaired, making PARP-mediated repair dependence therapeutically exploitable PARP inhibitors directly block oestrogen receptors BRCA loss causes universal microsatellite instability PARP inhibitors reverse all platinum resistance

Correct Answer:

Homologous recombination repair is impaired, making PARP-mediated repair dependence therapeutically exploitable

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