Medical Oncology SCE Practice Questions - Specialty Certificate Examination in Medical Oncology Exam - Medical Oncology SCE Practice Questions - Specialty Certificate Examination in Medical Oncology Exam

Question 1

Which statement best describes an actionable driver mutation in a solid tumour?

A somatic alteration that predicts benefit from a matched targeted therapy A germline variant found in every normal cell Any mutation with a high variant allele frequency A mutation that proves the tumour is metastatic

Correct Answer:

A somatic alteration that predicts benefit from a matched targeted therapy

Question 2

A colorectal cancer shows loss of MLH1 and PMS2 on immunohistochemistry. What is the most immediate implication?

The tumour should be assessed as mismatch repair deficient and Lynch syndrome or MLH1 promoter methylation considered The tumour is confirmed to be RAS wild type The patient cannot receive immune checkpoint inhibitors The finding is diagnostic of familial adenomatous polyposis

Correct Answer:

The tumour should be assessed as mismatch repair deficient and Lynch syndrome or MLH1 promoter methylation considered

Question 3

Which example is a predictive, rather than purely prognostic, biomarker?

HER2 amplification predicting benefit from trastuzumab Tumour stage predicting survival Performance status predicting treatment tolerance High grade predicting relapse risk

Correct Answer:

HER2 amplification predicting benefit from trastuzumab

Question 4

In lung cancer pathology, what does a PD-L1 tumour proportion score measure?

The percentage of viable tumour cells showing membranous PD-L1 staining The percentage of lymphocytes staining for CD8 The total number of tumour mutations per megabase The proportion of necrotic tumour in the biopsy

Correct Answer:

The percentage of viable tumour cells showing membranous PD-L1 staining

Question 5

Why can BRCA1 or BRCA2 loss make a tumour sensitive to PARP inhibition?

Homologous recombination repair is impaired, making PARP-mediated repair dependence therapeutically exploitable PARP inhibitors directly block oestrogen receptors BRCA loss causes universal microsatellite instability PARP inhibitors reverse all platinum resistance

Correct Answer:

Homologous recombination repair is impaired, making PARP-mediated repair dependence therapeutically exploitable

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About this Exam

Prepare with the Medical Oncology SCE Practice Questions - Specialty Certificate Examination in Medical Oncology Exam practice quiz. This question bank includes 100 questions covering cancer, patient, treatment, systemic, and metastatic. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Medical Oncology SCE Practice Questions - Specialty Certificate Examination in Medical Oncology Exam

This practice set contains 100 questions from the matching question bank and focuses on cancer, patient, treatment, systemic, and metastatic. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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Medical Oncology SCE Practice Questions - Specialty Certificate Examination in Medical Oncology Exam

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