Medical Oncology SCE Practice Questions - Specialty Certificate Examination In Medical Oncology Exam

A colorectal cancer shows loss of MLH1 and PMS2 on immunohistochemistry. What is the most immediate implication?

The tumour should be assessed as mismatch repair deficient and Lynch syndrome or MLH1 promoter methylation considered The tumour is confirmed to be RAS wild type The patient cannot receive immune checkpoint inhibitors The finding is diagnostic of familial adenomatous polyposis

Correct Answer:

The tumour should be assessed as mismatch repair deficient and Lynch syndrome or MLH1 promoter methylation considered

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