FRCS Neurosurgery Practice Questions - Intercollegiate Specialty Fellowship Examination In Neurosurgery (FRCS SN) Exam

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According to the WHO 2021 classification of CNS tumours, which combination of molecular features defines a 1p/19q-codeleted oligodendroglioma?

IDH-wildtype with EGFR amplification IDH-mutant with whole-arm codeletion of 1p and 19q IDH-mutant with ATRX loss and TP53 mutation H3 K27M mutation with loss of nuclear H3 K27me3

Correct Answer:

IDH-mutant with whole-arm codeletion of 1p and 19q

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