Facharzt FMH Dermatologie Und Venerologie Practice Questions - Facharzt FMH Für Dermatologie Und Venerologie Spécialiste FMH En Dermatologie Et Vénéréologie Exam

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A 42-year-old male presents with severe, chronic plaque psoriasis covering 22% of his body surface area (Psoriasis Area and Severity Index, PASI = 24) and concomitant severe psoriatic arthritis with dactylitis. He has a history of severe latent tuberculosis (completed 3 months of rifampin/isoniazid) and moderate Crohn's disease. Which class of biologic therapeutics is STRICTLY CONTRAINDICATED due to the risk of exacerbating or triggering inflammatory bowel disease (Crohn's disease)?

Interleukin-23 (IL-23) p19 inhibitors (e.g., Guselkumab, Risankizumab) Tumor Necrosis Factor-alpha (TNF-alpha) inhibitors (e.g., Infliximab, Adalimumab) Interleukin-12/23 p40 inhibitors (e.g., Ustekinumab) Interleukin-17 (IL-17) inhibitors (e.g., Secukinumab, Ixekizumab, Bimekizumab)

Correct Answer:

Interleukin-17 (IL-17) inhibitors (e.g., Secukinumab, Ixekizumab, Bimekizumab)

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