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Question 1
A 58-year-old male presents with a pigmented lesion on his upper back that has changed in size and color over the past 6 months. Dermoscopy reveals an asymmetric multicomponent pattern with atypical pigment network, irregular brown-black globules, and blue-white veil. An excisional biopsy is performed with 2 mm clinical margins. Histopathology confirms an invasive Superficial Spreading Melanoma with a Breslow thickness of 1.6 mm, presence of ulceration, and 2 mitoses/mm². According to current SGDV / EORTC / AJCC (8th edition) guidelines, what is the mandatory next step in surgical management?
Correct Answer:
Re-excision with a 1 cm radial surgical safety margin down to deep fascia and concurrent Sentinel Lymph Node Biopsy (SLNB)
Question 2
A 64-year-old female presents with multiple flaccid bullae on normal-appearing and erythematous skin of the trunk and scalp, along with painful, non-healing erosions of the oral buccal mucosa and hard palate. Gentle lateral tangential pressure on normal-appearing perilesional skin causes intraepidermal shearing and epidermal detachment (positive Nikolsky sign). Direct immunofluorescence (DIF) of perilesional skin reveals intercellular IgG and C3 deposition in a 'fishnet-like' (net-like) pattern throughout the epidermis. What is the target autoantigen in this autoimmune bullous disease?
Correct Answer:
Desmoglein 3 (and Desmoglein 1) in Pemphigus vulgaris
Question 3
A 78-year-old male with a history of Parkinson's disease presents with severe, generalized pruritus and tense, non-tender bullae on an urticarial erythematous base on his lower abdomen, inner thighs, and flexor aspects of the arms. Oral mucosa is completely spared. Nikolsky sign is negative. Direct immunofluorescence of perilesional skin demonstrates linear deposition of IgG and C3 along the dermal-epidermal basement membrane zone (BMZ). Enzyme-linked immunosorbent assay (ELISA) is strongly positive for antibodies targeting which specific molecular domain?
Correct Answer:
NC16A non-collagenous domain of BP180 (Type XVII Collagen) in Bullous pemphigoid
Question 4
A 42-year-old male presents with severe, chronic plaque psoriasis covering 22% of his body surface area (Psoriasis Area and Severity Index, PASI = 24) and concomitant severe psoriatic arthritis with dactylitis. He has a history of severe latent tuberculosis (completed 3 months of rifampin/isoniazid) and moderate Crohn's disease. Which class of biologic therapeutics is STRICTLY CONTRAINDICATED due to the risk of exacerbating or triggering inflammatory bowel disease (Crohn's disease)?
Correct Answer:
Interleukin-17 (IL-17) inhibitors (e.g., Secukinumab, Ixekizumab, Bimekizumab)
Question 5
A 32-year-old sexually active male presents with a solitary, painless, indurated ulcer with clean base and sharply demarcated, raised, cartilaginous borders on the coronal sulcus of the glans penis, accompanied by bilateral non-tender inguinal lymphadenopathy of 2 weeks' duration. Treponema pallidum particle agglutination (TPPA) and non-treponemal RPR are positive. What is the definitive first-line treatment for primary Syphilis according to European (IUSTI/EDF) and Swiss guidelines?
Correct Answer:
Benzathine Penicillin G 2.4 million units intramuscularly as a single dose
Question 1
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Prepare with the Facharzt FMH Dermatologie und Venerologie Practice Questions - Facharzt FMH für Dermatologie und Venerologie Spécialiste FMH en dermatologie et vénéréologie Exam practice quiz. This question bank includes 100 questions covering year-old, presents, male, reveals, and female. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Facharzt FMH Dermatologie und Venerologie Practice Questions - Facharzt FMH für Dermatologie und Venerologie Spécialiste FMH en dermatologie et vénéréologie Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, presents, male, reveals, and female. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

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