Facharzt FMH Dermatologie Und Venerologie Practice Questions - Facharzt FMH Für Dermatologie Und Venerologie Spécialiste FMH En Dermatologie Et Vénéréologie Exam

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A 78-year-old male with a history of Parkinson's disease presents with severe, generalized pruritus and tense, non-tender bullae on an urticarial erythematous base on his lower abdomen, inner thighs, and flexor aspects of the arms. Oral mucosa is completely spared. Nikolsky sign is negative. Direct immunofluorescence of perilesional skin demonstrates linear deposition of IgG and C3 along the dermal-epidermal basement membrane zone (BMZ). Enzyme-linked immunosorbent assay (ELISA) is strongly positive for antibodies targeting which specific molecular domain?

Desmocollin 1 in Subcorneal pustular dermatosis Laminin-332 (Laminin-5) in Anti-laminin mucous membrane pemphigoid NC16A non-collagenous domain of BP180 (Type XVII Collagen) in Bullous pemphigoid Alpha-6 / Beta-4 integrin in Ocular cicatricial pemphigoid

Correct Answer:

NC16A non-collagenous domain of BP180 (Type XVII Collagen) in Bullous pemphigoid

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