Facharzt FMH Dermatologie Und Venerologie Practice Questions - Facharzt FMH Für Dermatologie Und Venerologie Spécialiste FMH En Dermatologie Et Vénéréologie Exam

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A 64-year-old female presents with multiple flaccid bullae on normal-appearing and erythematous skin of the trunk and scalp, along with painful, non-healing erosions of the oral buccal mucosa and hard palate. Gentle lateral tangential pressure on normal-appearing perilesional skin causes intraepidermal shearing and epidermal detachment (positive Nikolsky sign). Direct immunofluorescence (DIF) of perilesional skin reveals intercellular IgG and C3 deposition in a 'fishnet-like' (net-like) pattern throughout the epidermis. What is the target autoantigen in this autoimmune bullous disease?

BP180 (Collagen XVII) and BP230 in Bullous pemphigoid Desmoglein 3 (and Desmoglein 1) in Pemphigus vulgaris Collagen VII in Epidermolysis bullosa acquisita Epidermal transglutaminase (eTG) in Dermatitis herpetiformis

Correct Answer:

Desmoglein 3 (and Desmoglein 1) in Pemphigus vulgaris

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