Cert Rheumatology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Rheumatology Cert Rheumatology(SA) Phys - South Africa Exam

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Why is Folic Acid supplementation (e.g., 5 mg weekly taken 24–48 hours after Methotrexate) routinely co-prescribed with Methotrexate in patients with Rheumatoid Arthritis?

It enhances the binding affinity of Methotrexate to dihydrofolate reductase in synovial macrophages It neutralizes circulating methotrexate anti-metabolites to prevent bone marrow aplasia It reduces gastrointestinal mucosal toxicity, stomatitis, and hepatic transaminase elevation without compromising DMARD efficacy It prevents methotrexate-induced acute renal tubular necrosis by alkalinizing the urine

Correct Answer:

It reduces gastrointestinal mucosal toxicity, stomatitis, and hepatic transaminase elevation without compromising DMARD efficacy

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