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Question 1
A 48-year-old woman presents with an 8-week history of symmetrical joint pain and swelling in both hands and wrists, accompanied by 2 hours of morning stiffness. On examination, she has synovitis in 4 PIP joints, 4 MCP joints, and both wrists (10 small joints total). Laboratory investigations reveal a high-positive anti-CCP antibody titer (>3 times upper limit of normal) and an elevated CRP level. According to the 2010 ACR/EULAR Classification Criteria for Rheumatoid Arthritis, what is her total classification score?
Correct Answer:
10 points (Joint involvement: 5, Serology: 3, Acute phase reactants: 1, Duration: 1)
Question 2
Which autoantibody possesses the highest specificity (>95%) for diagnosing Rheumatoid Arthritis and is strongly associated with progressive erosive joint damage?
Correct Answer:
Anti-cyclic citrullinated peptide (anti-CCP / ACPA)
Question 3
A 52-year-old male with active rheumatoid arthritis is initiated on Oral Methotrexate 15 mg weekly. Which of the following baseline laboratory monitoring panels is mandatory prior to commencing treatment?
Correct Answer:
Full blood count, liver transaminases (ALT/AST), serum creatinine/eGFR, chest X-ray, and Hepatitis B/C serology
Question 4
Why is Folic Acid supplementation (e.g., 5 mg weekly taken 24–48 hours after Methotrexate) routinely co-prescribed with Methotrexate in patients with Rheumatoid Arthritis?
Correct Answer:
It reduces gastrointestinal mucosal toxicity, stomatitis, and hepatic transaminase elevation without compromising DMARD efficacy
Question 5
Which of the following clinical features strongly distinguishes Rheumatoid Arthritis from Hand Osteoarthritis?
Correct Answer:
Symmetrical involvement of MCP and wrist joints with morning stiffness lasting more than 60 minutes
Question 1
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Prepare with the Cert Rheumatology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate in Rheumatology Cert Rheumatology(SA) Phys - South Africa Exam practice quiz. This question bank includes 100 questions covering year-old, presents, arthritis, woman, and severe. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Cert Rheumatology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate in Rheumatology Cert Rheumatology(SA) Phys - South Africa Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, presents, arthritis, woman, and severe. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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