Cert Medical Oncology(SA) Phys Practice Questions - Sub-specialty Certificate In Medical Oncology Of The College Of Physicians Of South Africa Exam

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A 54-year-old woman presents with newly diagnosed metastatic HER2-positive invasive breast cancer with multiple liver and bone metastases. Echocardiogram demonstrates a left ventricular ejection fraction (LVEF) of 62%. Baseline lab tests are normal. According to the landmark CLEOPATRA trial and international guidelines, what is the preferred first-line systemic regimen?

Trastuzumab emtansine (T-DM1) monotherapy Pertuzumab + Trastuzumab + Docetaxel Trastuzumab + Paclitaxel + Lapatinib Trastuzumab deruxtecan (T-DXd) + Capecitabine

Correct Answer:

Pertuzumab + Trastuzumab + Docetaxel

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