Cert Gastroenterology(SA) Phys Practice Questions - CMSA Sub-specialty Certificate In Gastroenterology Cert Gastroenterology(SA) Phys - South Africa Exam

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A 32-year-old male with chronic diarrhea and weight loss undergoes colonoscopy. Endoscopy shows multiple deep linear ulcers separated by normal mucosal mucosa ('cobblestoning') in the terminal ileum and ascending colon, with sparing of the rectum. Histopathological examination of biopsies reveals non-caseating granulomas within the submucosa. Which feature is most pathognomonic for Crohn's disease over Ulcerative Colitis?

Transmural inflammation and non-caseating epithelial granulomas Crypt abscesses and architectural distortion Continuous mucosal involvement starting from the anal verge Depletion of goblet cell mucin in mucosal crypts

Correct Answer:

Transmural inflammation and non-caseating epithelial granulomas

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