Chemical decontamination relies on selecting appropriate cleaners and disinfectants for the load and following safety precautions to protect staff. Enzymatic detergents help break down organic debris, making soils easier to remove; alkaline cleaners further loosen and lift soils. For equipment that can’t withstand heat sterilization, high-level disinfectants like glutaraldehyde or ortho-phthalaldehyde are used, but they require strict handling, correct contact times, and compatibility with the device. Safety measures include using the proper PPE, ensuring adequate ventilation to avoid exposure to fumes, and consulting the Safety Data Sheets for each chemical to understand hazards and first-aid steps. Proper mixing instructions must be followed, and mixing chemicals together should be avoided unless explicitly approved by label directions and the SDS. Household cleaners are not appropriate for medical device decontamination because they lack proven efficacy and the necessary safety data.