Question 1
Which type tends to be more in stomach than plasma?
Correct Answer:
Weak bases
Explanation:
Ion trapping driven by pH differences across compartments explains where a drug tends to accumulate. The stomach is highly acidic (low pH) while plasma is near neutral (pH ~7.4). For a weak base, the acidic environment protonates the molecule to form BH+, which is positively charged and crosses membranes poorly. As a result, the weak base remains largely in the stomach rather than moving into the bloodstream, so its concentration tends to be higher in the stomach than in plasma. Ethanol, by contrast, is not ionized and can freely cross membranes, so its distribution between stomach and plasma is more even. Weak acids become more unionized in acid and can cross into plasma, so they don’t concentrate in the stomach the same way.
Question 2
For IV administration, the drug must be in which form?
Correct Answer:
Aqueous solution
Explanation:
Intravenous administration requires the drug to be in an aqueous solution because the bloodstream is an aqueous environment and the medication must be readily dissolved to mix with blood and distribute quickly and predictably. An aqueous solution avoids particulate matter that could irritate or obstruct vessels, reducing the risk of embolism. It also allows proper control of dose, isotonicity, and sterility for safe IV use. Other forms pose problems: an oil suspension contains undissolved particles that may not distribute evenly and could cause embolic complications or require emulsification; a gas form could lead to air embolism; and a solid crystalline form would not dissolve, risking vessel blockage and unreliable dosing. Hence, an aqueous solution is the appropriate form for IV delivery.
Question 3
For the most rapid digestion, which ANS dominance leads to increased gastric emptying rate?
Correct Answer:
Parasympathetic dominance; increased gastric emptying
Explanation:
Parasympathetic dominance increases gastric motility and secretions, speeding up the movement of stomach contents into the small intestine. The vagus nerve stimulates smooth muscle contractions (peristalsis) and relaxes the pyloric sphincter, promoting faster gastric emptying. In contrast, sympathetic dominance constricts blood vessels, dampens GI smooth muscle activity, and slows or inhibits gastric emptying. So, the quickest digestion occurs when the parasympathetic system is dominant, leading to increased gastric emptying.
Question 4
A drug X is a weak base. Do you expect more drug in stomach or plasma?
Correct Answer:
Stomach
Explanation:
A weak base tends to accumulate in acidic environments due to ion trapping. In the stomach, pH is very low, so the weak base is largely protonated to form the conjugate acid. This charged form cannot cross membranes easily, so once the drug enters the stomach lumen, it gets trapped there and its concentration rises relative to plasma. In plasma, pH is near neutral, where the base exists more in its uncharged, membrane∝permeable form, so it doesn’t get trapped as much. Therefore, more drug is expected in the stomach than in the plasma.
Question 5
Which statement about absorption from the oral cavity is correct?
Correct Answer:
True
Explanation:
Absorption from the oral cavity can occur through the buccal or sublingual mucosa, allowing drugs to enter systemic circulation. This route is used for medicines designed for rapid effect or to bypass first-pass metabolism in the liver. Whether absorption happens depends on drug properties such as lipophilicity, molecular size, and the degree of ionization at saliva pH, as well as formulation and contact time with the mucosa. Because there is valid, real-world potential for absorption via the oral cavity for suitable drugs, the statement about absorption from this site being possible is true. The other options are less accurate because they suggest either no information, partial truth, or a false universal claim, whereas we know absorption can happen under the right conditions.
Question 1
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Prepare with the Pharmaceutics Xenobiotics Across Bio Membrane Practice Test practice quiz. This question bank includes 10 questions covering drug, rate, stomach, absorption, and plasma. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Pharmaceutics Xenobiotics Across Bio Membrane Practice Test

This practice set contains 10 questions from the matching question bank and focuses on drug, rate, stomach, absorption, and plasma. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

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