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Question 1
Which constellation of symptoms is typical of malaria in someone with recent endemic exposure?
Correct Answer:
Fever, fatigue, chills and anemia
Explanation:
Malaria characteristically causes febrile paroxysms with systemic symptoms in someone recently exposed in an endemic area. The intertwined fever and chills come from cyclical merozoite release from synchronized infected red blood cells, while fatigue reflects the body’s response to ongoing hemolysis. Anemia arises because parasite destruction of red blood cells, along with splenic clearance of affected and even some healthy cells, reduces oxygen-carrying capacity and causes weakness. While jaundice and hepatomegaly can occur with malaria, the most typical and distinguishing cluster is fever with chills plus anemia, especially after endemic exposure. The other symptom patterns align more with respiratory infection, viral arthritis, or isolated liver involvement and are less characteristic of malaria.
Question 2
Which red blood cell morphology is typical of iron deficiency anemia?
Correct Answer:
Microcytic hypochromic
Explanation:
Iron deficiency anemia causes less hemoglobin to be produced in each red blood cell, so the cells become smaller and carry less hemoglobin. This yields microcytic (small) and hypochromic (pale) red blood cells, a classic pattern seen on a blood smear. In other words, the hallmark morphology is microcytosis with reduced hemoglobin content. Early on, you might see normocytic normochromic RBCs, but as iron deficiency progresses, microcytic hypochromic becomes typical. For contrast, macrocytic cells appear with B12 or folate deficiency, and spherocytes arise from membrane disorders or autoimmune hemolysis, not iron deficiency.
Question 3
In a patient with suspected deep venous thrombosis, which initial test has high sensitivity to rule out DVT?
Correct Answer:
D-dimer
Explanation:
D-dimer is used as a rule-out test because it has high sensitivity for deep venous thrombosis. It measures a fibrin degradation product released when clots are formed and broken down. A negative D-dimer makes DVT unlikely in patients with low to intermediate pretest probability, so it can safely exclude DVT without imaging. A positive result isn’t specific for DVT—many conditions can raise D-dimer—so it must be followed by imaging, typically compression duplex ultrasound, to confirm whether a clot is present. Imaging studies like duplex ultrasound are more definitive but are used after D-dimer when the pretest probability isn’t clearly low. In short, the D-dimer’s high sensitivity makes it the best initial test to help rule out DVT.
Question 4
A cystocele is best described as which of the following?
Correct Answer:
Protrusion of the bladder through the anterior vaginal wall causing urinary incontinence.
Explanation:
A cystocele occurs when the bladder herniates into the anterior vaginal wall, usually due to weakening of the pelvic floor. This can manifest as a vaginal bulge and often leads to urinary symptoms such as leakage with increased abdominal pressure (stress incontinence). This is different from a uterine prolapse, where the uterus itself protrudes into the vaginal canal; a rectal prolapse involves prolapse of the rectum through the vaginal opening or anal canal; and an enterocele refers to prolapse of the small intestine into the vaginal canal, typically into the posterior vaginal wall. Therefore, the description matching a cystocele is the bladder protruding through the anterior vaginal wall with possible urinary incontinence.
Question 5
In epidemiology, the measure of a test's ability to correctly identify those without disease is called what?
Correct Answer:
Specificity
Explanation:
Specificity is the measure of a test's ability to correctly identify those without disease. It equals true negatives divided by the sum of true negatives and false positives (TN / [TN + FP]). A high specificity means few false positives, so a positive result strongly indicates disease being present. Sensitivity focuses on detecting those who have the disease (true positives among all with disease), predictive value deals with the probability of disease given a test result, and prevalence is how common the disease is in the population. Therefore, the described measure is specificity.
Question 1
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Prepare with the NBME Form 11 Practice Test practice quiz. This question bank includes 10 questions covering sensitivity, typical, therapy, future, and stings. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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NBME Form 11 Practice Test

This practice set contains 10 questions from the matching question bank and focuses on sensitivity, typical, therapy, future, and stings. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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