NBME CBSSA Practice Questions - NBME Comprehensive Basic Science Self-Assessment Exam - NBME CBSSA Practice Questions - NBME Comprehensive Basic Science Self-Assessment Exam

Question 1

A 23-year-old man develops dark urine and back pain 2 days after taking primaquine for malaria prophylaxis. Peripheral smear shows bite cells and Heinz bodies. Which biochemical abnormality most directly explains this reaction?

Impaired generation of NADPH in the pentose phosphate pathway Defective conversion of pyruvate to acetyl-CoA Decreased synthesis of heme from glycine and succinyl-CoA Impaired reduction of methemoglobin by cytochrome b5 reductase

Correct Answer:

Impaired generation of NADPH in the pentose phosphate pathway

Question 2

A newborn has bilious vomiting during the first day of life. Radiography shows air in the stomach and proximal duodenum with no distal bowel gas. Which embryologic process failed?

Physiologic herniation of the midgut into the umbilical cord Recanalization of the duodenal lumen Migration of neural crest cells into the distal colon Rotation of the midgut around the superior mesenteric artery

Correct Answer:

Recanalization of the duodenal lumen

Question 3

A 55-year-old man with exertional chest pressure has a fixed narrowing of the left anterior descending artery. During exercise, which local metabolic change primarily increases blood flow to the ischemic myocardium distal to the stenosis?

Increased adenosine concentration Increased endothelin release Decreased hydrogen ion concentration Decreased extracellular potassium concentration

Correct Answer:

Increased adenosine concentration

Question 4

A 7-year-old boy has recurrent skin abscesses and pneumonia caused by Staphylococcus aureus. Neutrophils fail to reduce nitroblue tetrazolium after stimulation. Which organism would create a similar clinical risk because it is catalase positive?

Streptococcus pyogenes Enterococcus faecalis Aspergillus fumigatus Clostridium tetani

Correct Answer:

Aspergillus fumigatus

Question 5

A 49-year-old woman has episodic burning pain in her hands and feet with redness. Laboratory studies show platelets of 950,000/mm3 and a JAK2 mutation. Which mechanism best explains her painful episodes?

Immune complex deposition in small vessels Platelet-mediated microvascular occlusion Defective collagen cross-linking in vessel walls Antibody-mediated destruction of peripheral nerves

Correct Answer:

Platelet-mediated microvascular occlusion

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Prepare with the NBME CBSSA Practice Questions - NBME Comprehensive Basic Science Self-Assessment Exam practice quiz. This question bank includes 100 questions covering year-old, shows, woman, develops, and pain. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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NBME CBSSA Practice Questions - NBME Comprehensive Basic Science Self-Assessment Exam

This practice set contains 100 questions from the matching question bank and focuses on year-old, shows, woman, develops, and pain. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

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NBME CBSSA Practice Questions - NBME Comprehensive Basic Science Self-Assessment Exam

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