When a patient voices hopelessness about treatment, the focus is on supportive, informative communication that validates feelings while providing realistic options. The best response is to invite a discussion about prognosis and treatment options. This approach acknowledges the patient’s emotional state and offers concrete information to help them understand what to expect, what choices are available, and how those choices might affect outcomes. It supports shared decision-making and helps restore a sense of control, rather than dismissing concerns or making promises that may not be true. Telling someone everything will be fine once treatment starts can feel dismissive and unrealistic, while suggesting that “everyone feels this way” after a diagnosis can minimize their individual experience. Asking “why do you feel this way?” can also come off as questioning the person’s emotions rather than inviting a helpful dialogue.