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Question 1
Chronic lymphocytic leukemia (CLL) is defined as the accumulation of which cells?
Correct Answer:
Monoclonal B cells
Explanation:
Chronic lymphocytic leukemia is characterized by a clonal expansion of mature B lymphocytes. These malignant cells are monoclonal B cells—meaning they all derive from a single B-cell clone—and they accumulate in blood, bone marrow, lymph nodes, and spleen. This B-cell–origin, clonality, and the resulting accumulation of small, mature-appearing lymphocytes define the disease. The other options point to different conditions: prolymphocytes can be involved in other leukemias and are not the defining cell type of CLL; hairy cells describe hairy cell leukemia with distinctive cytoplasmic projections and splenomegaly; thymic prolymphocytes refer to T-cell lineage in the thymus.
Question 2
Which statement about Heinz bodies in G6PD deficiency is true?
Correct Answer:
Visible only with supravital stain
Explanation:
Heinz bodies are precipitated denatured hemoglobin that forms in red cells after oxidative stress, which is especially evident in G6PD deficiency. They are not readily seen on routine Wright-Giemsa-stained smears because fixed cells don’t reveal these denatured Hb inclusions well. Supravital stains, used on living cells, specifically highlight denatured hemoglobin, making Heinz bodies appear as small dark inclusions near the inner surface of the red cell membrane. Prussian blue would stain iron, not Heinz bodies, so it wouldn’t reveal them. Therefore, the statement that Heinz bodies are visible only with supravital stain is correct.
Question 3
What is the MCHC if the Hct is 20%, the RBC is 2.4 x 10^6/µL, and the Hgb is 5 g/dL?
Correct Answer:
25%
Explanation:
MCHC shows how concentrated hemoglobin is inside red blood cells and is calculated from hemoglobin concentration and hematocrit. A common way to compute it is MCHC (%) = (Hgb in g/dL × 100) / Hct (%). Plugging in the values: (5 × 100) / 20 = 500 / 20 = 25%. So the MCHC is 25%, which is low and indicates hypochromia. This aligns with the very low hemoglobin and hematocrit, reflecting anemia with red cells that have less Hb concentration. The other data (RBC count or MCV) can complement the picture, but the key point is that the MCHC calculation gives 25%.
Question 4
HbE trait electrophoresis at pH 8.6 shows mobility with which hemoglobin?
Correct Answer:
HbA2
Explanation:
At alkaline pH 8.6, hemoglobins separate mainly by net charge; more negative charge makes a molecule migrate faster toward the anode. HbA moves the fastest, forming the fastest band, while HbA2 runs as a distinct, slower band. HbE is a beta-chain variant with a Glu-to-Lys substitution, which reduces the overall negative charge of the molecule. Because of this charge change, HbE migrates to the same position as HbA2 on alkaline electrophoresis, so the HbE trait appears in the HbA2 region. This is how HbE heterozygotes are detected on pH 8.6 electrophoresis.
Question 5
The Prussian blue staining of peripheral blood identifies:
Correct Answer:
Siderotic granules
Explanation:
Prussian blue staining targets ferric iron (Fe3+) in cells, turning iron deposits blue. In a peripheral blood smear, this stain highlights siderotic granules—iron-containing granules within neutrophils (and sometimes other cells)—which reflect stored iron such as ferritin or hemosiderin. This is distinct from reticulocytes (which require supravital stains to reveal RNA), Howell-Jolly bodies (DNA remnants seen on Wright-Giemsa), or basophilic stippling (ribosomal RNA aggregates). Therefore, the blue-stained granules indicate siderotic granules.
Question 1
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Prepare with the Hematology BOC 7th Ed. Practice Exam practice quiz. This question bank includes 10 questions covering g6pd, deficiency, peripheral, patient, and hematology. Use it to review important concepts, identify knowledge gaps, and build confidence for the related exam, course, or assessment.

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Hematology BOC 7th Ed. Practice Exam

This practice set contains 10 questions from the matching question bank and focuses on g6pd, deficiency, peripheral, patient, and hematology. Work through each question carefully, review the provided solutions, and revisit topics that need more study before your next attempt.

This is an independent study resource intended for practice and review; it is not an official examination or an endorsement by any organization named in the title.

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